NE1727: Influence of ovary, uterus, and embryo on pregnancy success in ruminants

(Multistate Research Project)

Status: Active

SAES-422 Reports

07/16/2018

Peer-reviewed journal articles published in 2017 reporting research from this project

Hale, B.J., Hager, C.J., Siebert, J.T., Selsby, J.T., Baumgard, L.H., Keating, A.F., Ross, J.W. 2017. Heat stress induces autophagy in pig ovaries during follicular development. Biology of Reproduction. 97(3):426-437.

Kvidera, S.K., Horst, E.A., Sanz-Fernandez, M.V., Abuajamieh, M., Ganesan, S., Gorden, P.J., Green, H.B., Schoenberg, K.M., Trout, W.E., Keating, A.F., Baumgard, L.H. 2017. Characterizing effects of feed restriction and glucagon-like peptide 2 administration on biomarkers of inflammation and intestinal morphology. Journal of Dairy Science. 100(11):9402-9417.

Ganesan, S., Dickson, M.J., Keating, A.F. Pesticides. In: Encyclopedia of Reproduction. In Press.

Ross, J.W., Hale, B.J., Seibert, J.T., Romoser, M. R., Adur, M.K., Keating, A.F., Baumgard, L.H. 2017. Physiological mechanisms through which heat stress compromises reproduction in pigs. Molecular Reproduction and Development.  84(9): 934-945.

McNeel AK, Vallet JL, Snelling WM, Wright EC, Larimore EL, Amundson OL, Miles JR, Chase Jr CC, Lents CA, Sonstegard TE, Schroeder SG, Wood JR, Cupp AS, Perry GA, and Cushman RA (2017) Beef heifers with diminished numbers of antral follicles have decreased uterine protein concentrations, Anim Reprod Sci 179:1-9 PMID: 28215453

Romereim SM, Summers AF, Pohlmeier WE, Zhang P, Hou X, Talbott HA, Cushman RA, Wood JR, Davis JS, and Cupp AS (2017) Gene expression profiling of bovine ovarian follicular and luteal cells provides insight into cellular identities and functions, Mol Cell Endocrinol 439:379-394 PMID: 27693538

Romereim SM, Summers AF, Pohlmeier WE, Zhang P, Hou X, Talbott HA, Cushman RA, Wood JR, Davis JS, and Cupp AS (2017) Transcriptomes of bovine ovarian follicular and luteal cells, Data in Brief 10:335-339 PMID: 28004024

Talbott H, Hou X, Qiu F, Guda C, Yu F, Cushman RA, Wood JR, Wang C, Cupp AS, and Davis JS (2017) Early transcriptome responses of the bovine mid-cycle corpus luteum to prostaglandin F2 alpha includes cytokine signaling, Mol Cell Endocrinology 452: 93-109, PMID: 28549990

Talbott H, Hou X, Qiu F, Zhang P, Guda C, Yu F, Cushman RA, Wood JR, Wang C, Cupp AS, and Davis JS (2017) Transcriptomic and bioinformatics analysis of the early time-course of the response to prostaglandin F2 alpha in the bovine corpus luteum, Data in Brief 14:695-706, PMCID: PMC5596332

Wood JR and Cupp AS (2017) Female Endocrinology –Aromatization. Encyclopedia of Reproduction, Second Edition (accepted, in press)

Águila L, Felmer R, Arias ME, Navarrete F, Martin-Hidalgo D5, Lee HC, Visconti P, Fissore R. 2017. Defective sperm head decondensation undermines the success of ICSI in the bovine.  Reproduction. 154:207-218.

Cerny, K.L., R.A.C. Ribeiro, Q. Li, J.C. Matthews and P.J. Bridges.  2017.  Effect of lipopolysachharide (LPS) on the expression of inflammatory mRNAs and microRNAs in the mouse oviduct.  Reproduction, Fertility and Development.  doi: 10.1071/RD17241.

Li, Q., R. Hegge, P.J. Bridges and J. C. Matthews.  2017.  Pituitary genomic expression profiles of steers are altered by grazing of high vs. low endophyte-infected tall fescue forages.  PLoS One.  12(9): e0184612.

Willis, E.L., P.J. Bridges and J.E. Fortune.  2017.  Progesterone receptor and prostaglandins mediate LH-induced changes in messenger RNAs for ADAMTS proteases in theca cells of bovine periovulatory follicles.  Molecular Reproduction and Development.  84:55-66.

Miles, E.D., B.W. McBride, P.J. Bridges and J.C. Matthews.  2017.  Effect of 17β-estradiol administration on hepatic expression of glutamine synthetase, β-catenin, and GPR30 in aged beef cows.  Canadian Journal of Animal Science.  97:281-289.

Hester J, Hanna-Rose W and Diaz FJ.  2017. Zinc depletion reduces fertility and disrupts oocyte development in C. elegans.  Comparative Biochemistry and Physiology 191, 203-209.

Tian X, Anthony K and Diaz FJ.  2017. Transition metal chelator induces progesterone production in mouse cumulus-oocyte complexes and corpora lutea. Biological Trace Mineral Research. doi:10.1007/s12011-016-0841-x.

Krumm, C. S., S. L. Giesy, L. S. Caixeta, W. R. Butler, H. Sauerwein, J. W. Kim, and Y. R. Boisclair. Effect of hormonal and energy-related factors on plasma adiponectin in transition dairy cows. J Dairy Sci. 100 (11):9418-9427, 2017.

Cheong, S. H., O. G. Sa Filho, V. A. Absalón Medina, A. Schneider, W. R. Butler, and R. O. Gilbert. Uterine and systemic inflammation influences ovarian follicular function in postpartum dairy cows. PLoS One 12 (5):e0177356, 2017.

Jaskiewicz NJ, Parisi S, Hermawan C, Townson DH 2017 O-GlcNAcylation enhances the tumorigenic properties of cervical cancer cells in vitro. Clinical Obstetrics, Gynecology and Reproductive Medicine 3(3):1-6

Mattos FCSZ, Canavessi AMO, Wiltbank MC, Bastos MR, Lemes AP, Mourao GB, Susin I, Coutinho LL, Sartori R (2017). Investigation of mechanisms involved in regulation of progesterone catabolism using an overfed versus underfed ewe-lamb model. J Anim Sci  95:5537-46.

Barletta RV, Maturana M, Carvalho PD, Del Valle TA, Netto AS, Renno FP, Mingoti RD, Gandra JR, Mourao GB, Fricke PM, Sartori R, Madureira EH, Wiltbank MC (2017). Association of changes among body condition score during the transition period with NEFA and BHBA concentrations, milk production, fertility, and health of Holstein cows. Theriogenology 104:30-6.

Hackbart KS, Bender RW, Carvalho PD, Vieira LM, Dresch AR, Guenther JN, Gencoglu H, Nascimento AB, Shaver RD, Wiltbank MC (2017). Effects of propylene glycol or elevated luteinizing hormone during follicle development on ovulation, fertilization, and early embryo development. Biol Reprod  97:550-63.

Pereira MHC, Wiltbank MC, Guida TG, Lopes FR, Vasconcelos JLM (2017B). Comparison of 2 protocols to increase circulating progesterone concentration before timed artificial insemination in lactating dairy cows with or without elevated body temperature. J Dairy Sci  100:8455-70.

Garcia-Guerra A, Motta JCL, Melo LF, Kirkpatrick BW, Wiltbank MC (2017A). Ovulation rate, antral follicle count, and circulating anti-Mullerian hormone in Trio allele carriers, a novel high fecundity bovine genotype. Theriogenology  101:81-90.

Garcia-Guerra A, Kirkpatrick BW, Wiltbank MC (2017B). Follicular waves and hormonal profiles during the estrous cycle of carriers and non-carriers of the Trio allele, a major bovine gene for high ovulation and fecundity. Theriogenology  100:100-13.

Prata AB, Pontes GCS, Monteiro PLJ, Drum JN, Wiltbank MC, Sartori R (2017). Equine chorionic gonadotropin increases fertility of grazing dairy cows that receive fixed-time artificial insemination in the early but not later postpartum period. Theriogenology  98:36-40.

Mollo MR, Monteiro PLJ, Surjus RS, Martins AC, Ramos AF, Mourao GB, Carrijo LHD, Lopes G, Rumpf R, Wiltbank MC, Sartori R (2017). Embryo production in heifers with low or high dry matter intake submitted to superovulation. Theriogenology  92:30-5.

Pereira MHC, Sanches CP, Guida TG, Wiltbank MC, Vasconcelos JLM (2017A). Comparison of fertility following use of one versus two intravaginal progesterone inserts in dairy cows without a CL during a synchronization protocol before timed AI or timed embryo transfer. Theriogenology  89:72-8.

Baez GM, Trevisol E, Barletta RV, Cardoso BO, Ricci A, Guenther JN, Cummings NE, Wiltbank MC (2017). Proposal of a new model for CL regression or maintenance during pregnancy on the basis of timing of regression of contralateral, accessory CL in pregnant cows. Theriogenology  89:214-25.

Sartori R, Spies C, Wiltbank MC (2017). Effects of dry matter and energy intake on quality of oocytes and embryos in ruminants. Reprod Fertil Dev  29:58-65.

Ochoa JC, Penagaricano F, Baez GM, Melo LF, Motta JC, Guerra AG, Meidan R, Ferreira JCP, Sartori R, Wiltbank MC (2017). Mechanisms for rescue of CL during pregnancy: Gene expression in bovine CL following intrauterine pulses of Prostaglandins E1 and F2alpha. Biol Reprod DOI:10.1093/biolre/iox183.

Toledo MZ, Baez GM, Garcia-Guerra A, Lobos NE, Guenther JN, Trevisol E, Luchini D, Shaver RD, Wiltbank MC (2017). Effect of feeding rumen-protected methionine on productive and reproductive performance of dairy cows. PLoS ONE  12:e0189117.

Wijma, M. M. Pérez, M. Masello, D. G. García, M. L. Stangaferro, and J.O. Giordano. 2017. A resynchronization of ovulation program based on ovarian structures present at nonpregnancy diagnosis reduced time to pregnancy in lactating dairy cows. J. Dairy Sci. 101:1697-1707.

Wijma, M.L. Stangaferro, M. Masello, G. E. Granados, and J.O. Giordano. 2017. Resynchronization of ovulation protocols for dairy cows including or not including gonadotropin-releasing hormone to induce a new follicular wave: Effects on re-insemination pattern, ovarian responses, and pregnancy outcomes. J. Dairy Sci. 100:7613-7625.

S.H. Cheong, O.G. Sá Filho, V.A. Absalon-Medina, A. Schneider, W.R. Butler, R.O. Gilbert. Uterine and systemic inflammation influences ovarian follicular function in postpartum dairy cows. PLoS ONE. 2017 May 12(5):e0177356 doi:https://doi.org/10.1371/journal.pone.0177356. PMID: 28542500

Ealy, A.D. and Wooldridge, L.K. 2017. The evolution of interferon-tau. Reproduction 154:F1-F10.

Hughes, C.K., Xie, M.M., McCoski, S.R. and Ealy, A.D. 2017. Activities for leptin in bovine trophoblast cells. Dom. Anim. Endocrinol. 58:84-89.

Kelley, D.E., Galvao, K.N., Mortensen, C.J., Risco, C.A. and Ealy, A.D. 2017. Using Doppler ultrasonography on day 34 of pregnancy to predict pregnancy loss in lactating dairy cattle. J. Dairy Sci. 100:3266-3271.

Lu, Y., Bradley, J.S., McCoski, S.R., Gonzalez, J.M., Ealy, A.D. and Johnson, S.E. 2017. Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling. Am. J. Regul. Integr. Comp. Physiol. 312:R806-R815. 

Lugar, D.W., Rhoads, M.L., Clark-Deener, S.G., Callahan, S.R., Revercomb, A.K., Prusa, K.J. and Estienne, M.J. (2017). Immunological castration temporarily reduces testis size and function without long-term effects on libido and sperm quality in boars. Animal 11:643-649.

MacGhee, M.E., Bradley, J.S., McCoski, S.R., Reeg, A.M., Ealy, A.D. and Johnson, S.E. 2017.  Plane of nutrition affects growth rate, organ size and skeletal muscle satellite cell activity in newborn calves. J. Anim. Physiol. Anim. Nutr. 101:475-483.

Reinholt, B.M., Bradley, J.S., Jacobs, R.D., Ealy, A.D. and Johnson, S.E. 2017. Tissue organization alters gene expression in equine induced trophectoderm cells. Gen. Comp. Endocrinol. 247:174-182. 

Talbot, N.C., Sparks, W.O., Phillips, C., Ealy, A.D., Powell, A.M., Caperna, T.J., Garrett, W.M., Donavan, D.M. and Blomberg, L.A. 2017. Bovine trophectoderm cells induced from bovine fibroblasts with induced pluripotent stem cell reprogramming factors. Mol. Reprod. Dev. 84:468-485.

Wilson, M.L., McCoski, S.R., Geifer, A.J., Akers, R.M., Johnson, S.E. and Ealy, A.D. 2017. The influence of postnatal nutrition on reproductive tract and endometrial gland development in dairy calves. J. Dairy Sci. 100:3243-3256.

Xie, M., McCoski S.R., Johnson, S.E., Rhoads, M.L. and Ealy, A.D. 2017. Combinatorial effects of epidermal growth factor, fibroblast growth factor 2 and insulin-like growth factor 1 on trophoblast cell proliferation and embryogenesis in cattle. Reprod. Fertil. Dev. 29:419-430.

Zezeski, A.L., McCracken, V.L., Poole, R.K., Al Naib, A., Smith, J.K., McCann, M.A. and Rhoads ML. (2017) Metabolic and reproductive characteristics of replacement beef heifers subjected to an early weaning regimen involving high-concentrate feeding. Animal 11:820-825.

 

Conference papers and abstracts/presentations:

Yost, E.E., Arzuaga, X., Carlson, L., Keating, A.F., Lehmann, G. 2017. Focusing and refining the evaluation of reproductive endpoints in a systematic review of PCBs.  International Symposium on Systematic Review and Meta-Analysis of Laboratory Animal Studies.

Ganesan, S., Nteeba, J. and Keating, A.F.  2017. Impact of glyphosate on ovarian signaling pathways regulating folliculogenesis and steroidogenesis. Society for the Study of Reproduction annual meeting. 

Hines, E.A., Romoser, M., Keating, A.F., Baumgard, L.H., Niemi, J., Williams, N.H., Haberl, B., Kerr, B., Touchette, K.T., Ross, J.W. 2017. Supplementation of arginine does not improve gilt reproductive performance under commercial conditions. Society for the Study of Reproduction annual meeting. 

Hines, E.A., Romoser, M., Keating, A.F., Baumgard, L.H., Niemi, J., Haberl, B., Kerr, B., Touchette, K., Ross, J.W. 2017. Effect of maternal arginine supplementation on offspring performance of pigs in a commercial production environment.  Importance of nutrition and environment on birth weight, muscle growth, health and survival of the neonate workshop meeting.

Baumgard, L.H., Kvidera, S.K., Horst, E.A., Dickson, M.J., Ydstie, J.A., Shouse, C.S., Mayorga, E.J., Al-Qaisi, M., Lei, S., Bidne, K.L., Seibert, J.T., Hall, B.J., Keating, A.F., Ross, J.W., Selsby, J.T., Rhoads, R.P. 2017. Consequences of leaky gut on the immune system, metabolism, physiology and animal performance. American Society of Dairy Science annual meeting.

Dickson, M.J., Kvidera, S.K., Horst, E.A., Ydstie, J.A., Bidne, K.L., Wiley, C.E., Gunn, P.J., Keating, A.F., Baumgard, L.H. Chronic lipopolysaccharide infusion has no impact on dominant follicular size but affects 17β-estradiol in lactating dairy cows.  American Society of Dairy Science annual meeting.

Kvidera, S.K., Horst, E.A., Sanz Fernandez, M.V., Abuajamieh, M., Ganesa, S., Gordon, P.J., Green, H.B., Schoenberg, K.M., Trout, W.E., Keating, A.F., Baumgard, L.H. 2017. Glucagon-like peptide 2 administration improves biomarkers of inflammation and intestinal morphology in feed restricted lactating Holstein cows.  American Society of Dairy Science annual meeting.

Kvidera, S.K., Dickson, M.J., Horst, E.A., Ydstie, J.A., Shouse, C.S., Bidne, K.L., Mayorga, E.J., Al-Qaisi, M., Ramirez, H.A., Keating, A.F., Baumgard, L.H. 2017. Effects of continuous and increasing lipopolysaccharide infusion on basal metabolism in lactating cows.  American Society of Dairy Science annual meeting.

Dickson, M.J., Kvidera, S.K., Horst, E.A., Ydstie, J.A., Shouse, C.S., Mayorga, E.J., Al-Qaisi, M., Bidne, K.L., Ramirez, H.A., Keating, A.F., Baumgard, L.H. 2017. Metabolic responses to a glucose tolerance test and epinephrine challenge post-continuous lipopolysaccharide infusion in lactating cows.  American Society of Dairy Science annual meeting.

Dickson, M.J., Kvidera, S.K., Horst, E.A., Ydstie, J.A., Shouse, C.S., Mayorga, E.J., Al-Qaisi, M., Bidne, K.L., Ramirez, H.A., Keating, A.F., Baumgard, L.H. 2017. Chronic lipopolysaccharide infusion reduces productivity in lactating dairy cows.  American Society of Dairy Science annual meeting.

McCain AR, Beede KA, Yates DT, and Wood JR (2017) Maternal and Paternal Obesity Differentially Affect Fetal Growth with Maternal Obesity Associated Growth Restriction Attributed to Decreased 11-Hydroxysteroid Dehydrogenase Expression Society for the Study of Reproduction, Washington, DC

Timme KA, Xie F, Davis JS, and Wood JR (2017) Ovarian Inflammation and Oxidative Stress Associated with Diet Induced Obesity (DIO) Impacts RNA-Binding Protein Expression and Potentially mRNA Stability in the Murine Ovary and Oocyte.  Society for the Study of Reproduction, Washington, DC

Romereim SM, Summers AF, Pohlmeier WE, McFee RM, Spuri-Gomes R, Kurz SG, Davis JS, Wood JR, and Cupp AS (2017) A High-Androgen Microenvironment Inhibits Granulosa Cell Proliferation and May Alter Cell Identity. Society for the Study of Reproduction, Washington, DC

Abedal-Majed MA, Hart ML, Largen V, Magamage MPS, Kurz SG, Sargent KM, Bergman J, McFee RM, Cushman RA, Davis JS, Wood JR, and Cupp AS (2017) Ovarian Cortex from High A4 Cows Secrete Excess A4 and Exhibits Increased Oxidative Stress, Macrophage Markers and Arrested Follicle Development Which can be Partially Rescued by Angiogenic VEGFA Isoforms. Society for the Study of Reproduction, Washington, DC

Nafziger S, Abedal-Majed MA, Tenley S, Summers A, Hart ML, Harsh G, Bergman J, Kurz SG, Wood JR, Cushman RA, and Cupp AS (2017) Endocrine Profiles during Attainment of Puberty may Predict Reproductive Longevity in Heifers. Society for the Study of Reproduction, Washington, DC

Wood JR (2017) Maternal Obesity, the Gut Microbiota, and Oocyte mRNAs: Potential Impact on the Developing Embryo and Fetus. 4th World Congress on Reproductive Biology, Naha, Okinawa, Japan (invited speaker)

McCain AR, Beede KA, Yates DT, Shankar K, and Wood JR (2017) Maternal Obesity Results in Fetal Growth Restriction Associated with Reduced Placental Efficiency and an Altered Placental Transcriptome. 14th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS

Timme KA, Xie F, Davis JS, and Wood JR (2017) Ovarian Inflammation and Oxidative Stress Associated with Diet Induced Obesity (DIO) Impacts RNA-Binding Protein Expression and Potentially mRNA Stability in the Murine Ovary and Oocyte. 14th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS

Nafziger S, Abedal-Majed MA, Tenley S, Summers AF, Hart ML, Harsh G, Bergman J, Kurz SG, Wood JR, Cushman RA, and Cupp AS (2017) Endocrine Profiles during Attainment of Puberty may Predict Reproductive Longevity in Heifers. 14th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS

Abedal-Majed MA, Hart ML, Largen V, Magamage MPS, Kurz SG, Sargent KM, Bergman J, McFee RM, Cushman RA, Davis JS, Wood JR, and Cupp AS (2017) Ovarian Cortex from High A4 Cows Secrete Excess A4, and Exhibit Increased Oxidative Stress and Arrested Follicle Development which can be Partially Rescued by Angiogenic VEGFA Isoforms. 14th Annual Gilbert Greenwald Symposium on Reproduction, Kansas City, KS

Wijma, M. Masello, M. L. Stangaferro, M. M. Pérez, and J. O. Giordano. 2017. A resynchronization of ovulation strategy based on the ovarian structures present at non-pregnancy diagnosis reduced time to pregnancy in lactating dairy cows. J. Dairy Sci. Volume 100, E-Supplement 2.

E.M. Sitko, S.H. Cheong 2017 Longitudinal study of metritis risk in dairy cattle. Clinical Theriogenology Sep; 9(3):432.

Ardestani G, Mehregan A, Carvacho I, He C, Fissore RA. Expression and Function of Cation Permeable Channels in Mouse GV oocytes. Gordon Research Conferences. July 2017- Fertilization and Activation of Development. New Hampshire. Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003.

Huang, P.J. Bridges and J.C. Matthews. 2017. Shifts in hepatic transcriptome profiles of growing versus finished beef steers. Journal of Animal Science 95 (Supplement 4) doi:10.2527/asasann.2017.326.

Huang, Y. Jia, Q. Li, W.R. Burris, P.J. Bridges and J.C. Matthews. 2017. GTRAP3-18 protein negatively modulates canalicular glutamate transport and glutamine synthesis capacity in the liver of finishing versus growing beef steers.  Journal of Animal Science 95 (Supplement 4) doi:10.2527/asasann.2017.327.

Li, P.J. Bridges and J.C. Matthews. 2017. Summer-long grazing of endophyte-infected tall fescue by growing beef steers inhibits expression of genes responsible for prolactin and ACTH synthesis. ASAS 2017 Southern Section Meeting. doi:10.2527/ssasas2017.058

Jia, Q. Li, G.E. Aiken, P.J. Bridges and J.C. Matthews. 2017. Effects of Selenium-form Phenotypes on Steers Grazing Endophyte-Infected Tall Fescue.  ASAS 2017 Southern Section Meeting. doi:10.2527/ssasas2017.057.

Fetter, ME, Pate, JL, Harvatine, KJ, Moats, J and Ott, TL. 2017. Effects of feeding an extruded flaxseed supplement on fatty acids in milk and plasma and immune function in transition dairy cows. Annual Meeting of the American Dairy Science Association, Pittsburg, PA.

Hughes CK and Pate JL. 2017. Differentially expressed proteins, transcripts, and miRNA in the corpus luteum during maternal recognition of pregnancy indicate matrix remodeling and miRNA regulation during luteal rescue. Proceedings of the 50th annual meeting of the Society for the Study of Reproduction, Washington, DC.

Wetzel L, Inskeep EK and Pate JL. 2017. The importance of the luteal microenvironment for programming resident macrophages. Proceedings of the 50th annual meeting of the Society for the Study of Reproduction, Washington, DC.

Pate JL and Hughes CK. 2017. Cell and networks the facilitate luteal survival for pregnancy success. Proceedings of the 4th World Congress on Reproductive Biology, Okinawa, Japan.

Pate JL, Maalouf SA and Hughes CK. 2017. MicroRNA as regulators of luteal function. Proceedings of the 37th annual meeting of the American Society of Reproductive Immunology, Chicago.

Kutchy NA, Menezes ESB, Wills RW, Tan W, Kaya A, Topper E, Didion BA, Moura AA, Perkins A, Memili E. (2017) Sperm Nuclear Proteins are Associated with Bull Fertility. Presented at the International Conference of Society for the Study of Reproduction. Washington, DC. July 13-16, 2017.

Kutchy NA, Menezes E, Moura A, Kaya A, Perkins A, Memili E. (2017) Sperm Epigenomic and Genomic Determinants Regulating Male Fertility. Gordon Research Conference on Fertilization & Activation of Development: Uniting Eggs and Sperm, from Fundamentals to Applications. Holderness, NH July 16-21, 2017.

Haynes, BP, Kutchy NA, Menezes ESB, Ugur MR, Tan W, Moura A, Kaya A, Memili E. (2017) Epigenetic Control of Male Fertility through Sperm Histone 4. Undergraduate Research Symposium, Mississippi State University, April 13, 2017.

Ugur MR, Kutchy NA, Menezes SBE, Kaya A, Moura A, Perkins A, Memili E. (2017) Sperm- and Oocyte-born MicroRNA Transcripts Regulating Early Mammalian Embryogenesis and Fertility. Mississippi State University’s Graduate Student Association’s Symposium, March 25, 2017.

Kutchy NA, Menezes ESB, Chiappetta A, Kaya A, Moura A, Perkins A, Memili E. (2017) Sperm Chromatin Dynamics Modulated by Acetylated and Methylated Sperm Histone 3 (H3K27ac and H3K27me3) are Associated with Male Fertility. Triangle Consortium for Reproductive Biology (TCRB) Conference, Research Triangle Park, NC, February 25, 2017.

Koganti PP, Wang J and Yao J. Identification and Functional Prediction of Bovine Oocyte-Specific Long Non-Coding RNAs. 50th Annual Meeting of the Society for the Study of Reproduction. Washington D.C. July 13-16, 2017.

Zhang M, Hand JM, Smith GW and Yao J. Determination of the consensus target sequences recognized by ZNFO, a novel oocyte-specific zinc finger transcription factor in cattle. 50th Annual Meeting of the Society for the Study of Reproduction. Washington D.C. July 13-16, 2017.

Harl, A.W., E.L. Larimore, A. Al Naib†, L.K. Wooldridge, A.D. Ealy, G.A. Perry and M.L. Rhoads. 2017. Maturation of bovine cumulus-oocyte complexes with follicle fluid varying in estradiol content affects cumulus cell expansion without affecting subsequent embryo development in vitro. 2017 IETS Annual Meeting, Austin, TX.

J.O. Giordano. Integrating automated detection of estrus in reproductive management programs for dairy cattle. Precision Dairy Management Conference. Lexington, KY. May 30th, 2017.

J.O. Giordano. Update on reproductive physiology and reproductive management programs of lactating dairy cows. Technical services training program. Boehringer Ingelheim Vetmedica. Portland, OR. June 22nd, 2017.

J.O. Giordano. Reproductive Physiology and Management of Dairy Cattle. Alta Genetics Dairy Manager School for Spanish speaking managers. Alta Genetics. Watertown, WI. July 17th and 18th, 2017.

J.O. Giordano. Reproductive Physiology and Management of Dairy Cattle. Alta Genetics Dairy Manager School for Spanish speaking managers. Alta Genetics. Tulare, CA. May 23rd, 2017.

J.O. Giordano. 1. Practical aspects of reproductive physiology. 2. Current reproductive management strategies for dairy cattle. Eastern New York Dairy Day. Cooperstown, NY. March 28th, 2017.

J.O. Giordano. Reproductive Physiology and Management of Dairy Cattle. Alta Genetics Dairy Manager School. Alta Genetics. Gainesville, FL. March 9th, 2017.

J.O. Giordano. Reproductive Physiology and Management of Dairy Cattle. Alta Genetics Dairy Manager School. Alta Genetics. Gainesville, FL. February 20th, 2017.

J.O. Giordano. Ohio Dairy Health and Management Certificate Program: Dairy Cattle Reproduction with Emphasis on Transition Cow Management in Confinement Systems. 1. Automating Health Monitoring in Dairy Farms. 2. Automating Health Monitoring in Dairy Farms. College of Veterinary Medicine, The Ohio State University, Columbus, Ohio. February 2nd, 2017.

J.O. Giordano. Automating Reproductive and Health Management in Dairy Farms. GEA Technologies technical services team training program. Puerto Vallarta, Mexico. January 18th, 2017.

 

Extension reports:

Romereim SM, Tenley SC, Abedal-Majed MA, Bergman JW, Kurz SG, Davis JS, Wood JR, and Cupp AS (2017) Letrozole: A Steroid-Free Estrous Synchronization Method. Nebraska 2017 Beef Cattle Report, in press

 

Theses/Dissertations:

Abedal-Majed, MA (2017) Effect of Post-Weaning Diet, Excess Androstenedione, and Vascular Endothelial Growth Factor A (VEGFA) Isoforms on Follicular Progression in Bovine Ovarian Cortical Cultures (Nebraska).

Joseph Miseirvitch (2017). Regulation of CCN1 Expression by PGF and PKC Signaling in Human Ovarian Granulosa Cells (New Hampshire).

McCauley Vailes (2017). Post-Transfer Outcomes in Cultured Bovine Embryos Supplemented with Epidermal Growth Factor, Fibroblast Growth Factor 2, and Insulin-Like Growth Factor 1. (Virginia).

Benjamin R. Crites (2017).  Comparison of conception rates in beef cattle inseminated with either SEXEDULTRA™ sex-sorted semen or conventional semen in fixed-time artificial insemination (FTAI) protocols (Kentucky).

Benjamin Hale (2017). Two components of maintaining developmental competence: MicroRNA-21 in the maturing oocyte and autophagy induction in the follicular stage ovary (Iowa).

Katie L. Bidne (2017). Investigating the ovarian response to endotoxemia (Iowa).

Mackenzie J. Dickson (2017). Impact of endotoxemia on ovarian signaling and function (Iowa).

 

Active collaboration within the group

NY, PA, NH, VT and WV:  Samples collected to investigate associations between fertility outcomes and SNP in candidate genes from dairy cows.

IA and UK: Samples shared to determine the effect of LPS treatment on ovarian inflammation.

PA and WV: Samples shared for analysis of molecular regulators of luteal function.

VT and NY: Samples assayed (NY) for analysis of progesterone concentrations.

NY and WI:  Samples collected to investigate the effect of supplementation with rumen-protected methionine on reproductive traits of lactating dairy cows.

 

In addition to Hatch Multistate Funds, these studies were supported by:

National Institute of Environmental Health Science (AK)     

National Institutes of Health (FD)

USDA-National Institute of Food and Agriculture (AK, PB, JP, EM, MR, AE, SHC, JG, MW)

USDA-ARS Specific Cooperative Agreement (SCA) with the Forage and Animal Production Research Unit (FAPRU), Lexington, KY (PB)

Virginia Agricultural Council Research Funding (AE, MR)

Iowa Pork Producers Association (AK)                                                                                             

National Pork Board (AK)

National Institute of Food and Agriculture (AK)

Iowa Pork Industry Center (AK)

Iowa State University Bailey Career Development Award (AK)

Lee Rumberger and Family Endowment (JP)

Alta Genetics, Inc. (EM)

Brasil Programa de Doutorado Integrado em Zootecnia – PDIZ/UFC and Conselho Nacional de Desenvolvimeno Científico e Tecnológico – CNPq (EM)

New York Farm Viability Institute (JG)

Adisseo (JG, MW)

Zoetis (JG)

 

08/19/2019

Peer-reviewed journal articles reporting research from this project

 

Abuajamieh, M, Kvidera, SK, Mayorga, EJ, Kaiser, A, Lei, S, Seibert, JT, Horst, EA, Sanz Fernandez, MV, Ross, JW, Selsby, JT, Keating, AF, Rhoads, RP, Baumgard, LH 2018. The effect of recovery from heat stress on circulating bioenergetics and inflammatory biomarkers. Journal of Animal Science. 96(11):4599-4610.

 

Horst, EA, Kvidera, SK, Mayorga, EJ, Shouse, CS, Al-Qaisi, M, Dickson, MJ, Ydstie, J, Ramirez Ramirez, HA, Keating, AF, Dickson, DJ, Griswold, KE, Baumgard, LH. 2018. Effect of chromium on bioenergetics and leukocyte dynamics following immunoactivation in lactating Holstein cows. Journal of Dairy Science. 101(6):5515-5530.

 

Hristov, AN,  Degaetano, AT,  Rotz, CA, Hoberg, E, Skinner, RH, Felix, T, Li, H, Patterson, PH, Roth, G, Hall, M, Ott, TL, Baumgard, LH, Staniar, W, Hulet, RM, Dell, CJ, Brito, AF, Hollinger, DY. 2018. Climate change effects on livestock in the Northeast US and strategies for adaptation. Climatic Change 146 (1-2); pgs 33-45 doi.org/10.1007/s10584-017-2023-z

 

Hughes CK, Maalouf SW Liu W-S, Pate JL. 2019. Molecular profiling demonstrates modulation of immune cell function and matrix remodeling during luteal rescue. Biology of Reproduction, 2019, 0(0), 1–16 doi:10.1093/biolre/ioz037 Research Article Advance Access Publication Date: 27 March 2019

 

Hughes CK, Pate JL. 2019. Luteolysis and the Corpus Luteum of Pregnancy. In: The Ovary 3rd Edition, PCK Leung and EY Adashi, eds., Academic Press, Elsevier, pp. 270-295.  ISBN 978-0-12-813209-8

 

Ott, TL. 2019. Symposium Review: Immunological detection of the ruminant conceptus. Journal of Dairy Science 104(4): pgs 3766-3777 doi.org/10.3168/jds.2018-15668 

 

Pate JL, Hughes CK. 2018. Applications of large-scale molecular profiling techniques to the study of the corpus luteum. Anim. Reprod. 15:Suppl. 1, p. 791-804. DOI: 10.21451/1984-3143-AR2018-0038

 

Pate, JL. 2018. Luteolysis. In M. K. Skinner (Ed.), Encyclopedia of Reproduction. vol. 2, pp. 106–113. Academic Press: Elsevier. http://dx.doi.org/10.1016/B978-0-12-801238-3.64397-0

 

Silveira, PAS, WR Butler, SE LaCount, TR Overton, CC Barros, and A Schneider. 2019. Polymorphisms in the anti-oxidant paraoxonase-1 (PON1) gene associated with fertility of postpartum dairy cows. Theriogenology 125:302-309.

 

Bedford A, Beckett L, Hardin K, Dias NW, Davis T, Mercadante VR, Ealy AD and White RR. 2018. Propionate affects insulin signaling and progesterone profiles in dairy heifers. Sci. Rep. 8:17629.

 

Bonometti S, Menarim BC, Reinholt BM, Ealy AD and Johnson SE. 2019. Growth factor modulation of equine trophoblast mitosis and prostaglandin gene expression. J. Anim. Sci. 97:865-873. 

 

Ealy AD, Wooldridge LK and McCoski SR. 2019. Post-transfer consequences of in vitro-produced embryos in cattle. J. Anim. Sci. ePub 04/10/2019. 

 

Fontes PL, Oosthuizen N, Ciriaco FM, Sanford CD, Canal LB, Pohler KG, Henry DD, Mercadante VR, Timlin CL, Ealy AD, Johnson SE, DiLorenzo N and Lamb GC. 2019. Impact of fetal vs. maternal contributions of Bos indicus and Bos taurus genetics on embryonic and fetal development. J. Anim. Sci. 97:1645-1655.

 

McCoski SR, Poole RK, Vailes MT and Ealy AD. 2018. Maternal obesity alters the expression of embryonic regulatory transcripts in the preimplantation ovine conceptus. Repro. Biol. 18:198-201.

 

McCoski SR, Vailes MT, Owens, CE Cockrum RR and Ealy AD. 2018. Exposure to maternal obesity alters gene expression in the preimplantation ovine conceptus. BMC Genomics 19:737.

 

Vailes MT, McCoski SR, Wooldridge LK, Reese ST, Pohler KG, Roper DA, Mercadante VR and Ealy AD. 2019. Post-transfer outcomes in cultured bovine embryos supplemented with epidermal growth factor, fibroblast growth factor 2, and insulin-like growth factor 1. Theriogenology 124:1-8.

 

Wooldridge LK and Ealy AD. 2019. Interleukin-6 increases inner cell mass numbers in bovine embryos. BMC Dev. Biol. 19:2.

 

Zhang Z, Zhao LD, Johnson SE, Rhoads ML, Jiang H and Rhoads RP. 2019. Oxytocin is involved in steroid hormone-stimulated bovine satellite cell proliferation and differentiation in vitro. Domest. Anim. Endocrinol. 66:1-13.

 

Carvalho PD, Santos VG, Giordano JO, Wiltbank MC, Fricke PM. 2018. Development of fertility programs to achieve high 21-day pregnancy rates in high-producing dairy cows. Theriogenology 2018; 114:165-172.  10.1016/j.theriogenology. 03.037

 

Garcia-Guerra A, Canavessi AMO, Monteiro PLJ, Jr., Mezera MA, Sartori R, Kirkpatrick BW, Wiltbank MC. 2018. Trio, a novel bovine high fecundity allele: III. Acquisition of dominance and ovulatory capacity at a smaller follicle size. Biol Reprod 98:350-365.  10.1093/biolre/iox157

 

Garcia-Guerra A, Kamalludin MH, Kirkpatrick BW, Wiltbank MC. 2018. Trio a novel bovine high-fecundity allele: II. Hormonal profile and follicular dynamics underlying the high ovulation rate. Biol Reprod 98:335-349.  10.1093/biolre/iox156

 

Garcia-Guerra A, Wiltbank MC, Battista SE, Kirkpatrick BW, Sartori R. 2018. Mechanisms regulating follicle selection in ruminants: lessons learned from multiple ovulation models. Animal Reproduction 15:660-679. 

 

Kamalludin MH, Garcia-Guerra A, Wiltbank MC, Kirkpatrick BW. 2018. Proteomic analysis of follicular fluid in carriers and non-carriers of the Trio allele for high ovulation rate in cattle. Reprod Fertil Dev  10.1071/RD17252

 

Kamalludin MH, Garcia-Guerra A, Wiltbank MC, Kirkpatrick BW. 2018. Trio, a novel high fecundity allele: I. Transcriptome analysis of granulosa cells from carriers and noncarriers of a major gene for bovine ovulation rate. Biol Reprod 98:323-334.  10.1093/biolre/iox133

 

Melo LF, Monteiro PLJ, Jr., Nascimento AB, Drum JN, Spies C, Prata AB, Wiltbank MC, Sartori R. 2018. Follicular dynamics, circulating progesterone, and fertility in Holstein cows synchronized with reused intravaginal progesterone implants that were sanitized by autoclave or chemical disinfection. J Dairy Sci 101:3554-3567.  10.3168/jds.2017-13570

 

Melo LF, Monteiro PLJ, Jr., Oliveira LH, Guardieiro MM, Drum JN, Wiltbank MC, Sartori R. 2018. Circulating progesterone concentrations in nonlactating Holstein cows during reuse of intravaginal progesterone implants sanitized by autoclave or chemical disinfection. J Dairy Sci 101:3537-3544.  10.3168/jds.2017-13569

 

Ochoa JC, Penagaricano F, Baez GM, Melo LF, Motta JCL, Garcia-Guerra A, Meidan R, Pinheiro Ferreira JC, Sartori R, Wiltbank MC. 2018. Mechanisms for rescue of corpus luteum during pregnancy: gene expression in bovine corpus luteum following intrauterine pulses of prostaglandins E1 and F2alpha. Biol Reprod 98:465-479.  10.1093/biolre/iox183

 

Silva EP, Wiltbank MC, Machado AB, Gambin LS, Dias MM, Chaiben MFC, Bernardi ML, Borges JBS. 2018. Optimizing timed AI protocols for Angus beef heifers: Comparison of induction of synchronized ovulation with estradiol cypionate or GnRH. Theriogenology 121:7-12.  10.1016/j.theriogenology.2018.07.019

 

Vasconcelos JLM, Pereira MHC, Wiltbank MC, Guida TG, Lopes Jr. FR, Sanches Jr. CP, Barbosa LFSP, Costa Jr. WM, Munhoz AK. 2018. Evolution of fixed-time AI in Brazil. Animal Reproduction 15: 940-951. 

 

Wiltbank MC, Mezera MA, Toledo MZ, Drum JN, Baez GM, Garcia-Guerra A, Sartori R. 2018. Physiological mechanisms involved in maintaining the corpus luteum during the first two months of pregnancy. Animal Reproduction 15:805-821.

 

Tenley SC, Spuri-Gomes R, Rosasco SL, Northrop EJ, Rich J, McNeel AK, Summers AF, Miles JR, Chase CC, Lents CA, Perry GA, Wood JR, Cupp AS, Cushman RA. 2018. Maternal Age Influences the Number of Primordial Follicles in the Ovaries of Yearling Angus Heifers, Animal Reproduction Science 200:105-112

 

McFee RM, Cupp AS, and Wood JR. 2018. Use of case-based or hands-on lab exercises with physiology lectures improves knowledge retention but veterinary medicine students prefer case-based activities, Adv Physiology Education, 42(2):182-191

 

Wood JR, and Cupp AS. 2018. Aromatization. In M. K. Skinner (Ed.), Encyclopedia of Reproduction. vol. 2, pp. 195–201. Academic Press: Elsevier. http://dx.doi.org/10.1016/B978-0-12-801238-3.64642-1

 

Ganesan, S, Dickson, MJ, Keating, AF. 2018. Pesticides. In M. K. Skinner (Ed.), Encyclopedia of Reproduction. vol. 2, pp. 724–730. Academic Press: Elsevier.

Clark, KL, Ganesan, S, Keating, AF. 2018. Impact of Toxicant Exposures on Ovarian Gap Junctions. Reproductive Toxicology. 81:140-146.

Bidne, KL, Dickson, MJ, Ross, JW, Baumgard, LH, Keating, AF. 2018. Disruption of female reproductive function by endotoxins. Reproduction. 155(4):R169-R181.

 

 

Conference papers and abstracts/presentations

Clark, KL, Talton, O, Ganesan, A, Schulz, LC, Keating AF. 2018. Lean maternal gestational diabetes mellitus impacts the ovarian proteome basally and in response to a stressor in later life. Society for the Study of Reproduction annual meeting, New Orleans.

 

Parrish, JJ, Keating, AF, Pate, JL, Pohler, KG, Wiltbank, MC, Ealy, AD. 2018. Changing paradigm in graduate education: Collaborative on-line approach in Reproduction. American Society of Animal Science annual meeting.

 

Piet S, Walker S, Tsang PCW.  2019. Expression and Regulation of Cysteine Rich 61-Connective Tissue Growth Factor-Nephroblastoma Overexpressed (CCN1) in Ovarian Adenocarcinoma (OVCAR8) Cells. 52nd Annual Meeting of the Society for the Study of Reproduction, San Jose, CA.

 

Wiltbank MC, Carvalho PD, Barletta RV, Fricke PM, Shaver RD. 2018. Relationships Among Changes in Body Condition Score and Reproductive Efficiency in Lactating Dairy Cows. 27th Tri-State Dairy Nutrition Conference 2018:121-138. 

 

Goulet M, Donahue J, Tsang PCW. 2019. Regulation of the Angiogenic Inducer, Cysteine Rich 61-Connective Tissue Growth Factor-Nephroblastoma Overexpressed 1 (CCN1), in Bovine Luteal Cells. 52nd Annual Meeting of the Society for the Study of Reproduction, San Jose, CA.

 

Lundberg, Jaskiewicz NJ, Townson DH. 2019. Stimulatory effects of Transforming Growth Factor-alpha in bovine granulosa cells of small antral follicles. Society for the Study of Reproduction Annual Meeting

 

Arbeithuber B, Stoler N, Higgins B, Hester JM, Diaz F, Nekrutenko A, Makova KD. 2018. Rare mitochondrial DNA variant analysis in single oocytes using duplex sequencing. 31st annual meeting of The Biology of Genomes. Cold Springs Harbor Laboratory.  Cold Springs Harbor, NY. May 8-12.

 

Baddela VS, Hughes CK and Pate JL. 2018. Let7 miRNA are abundant in the bovine corpus luteum and regulate cellular metabolic functions Society for the Study of Reproduction, New Orleans, LA

 

Butler WR, Schneider A, Silveira PAS, Townson DH, Tsang PCW, Dailey RA, Ott TL and Pate JL. 2018. Effects of polymorphisms in GHR, IGF-I and TNFα genes on fertility in lactating dairy cows. Amer Dairy Sci Association

 

Butler, W.R., Schneider., A., Silveira. P.A.S., Townson, D.H., Tsang, P.C.W., Dailey, R.A., Diaz FJ. 2018. Sufficient Dietary Zinc During the Preconception Period is Essential for Oocyte Competence.  Endocrine Society Annual Meeting, Chicago, IL. March 17-20.

 

Harper, MT, Oh, J, Melgar, A, Nedelkov, K, Räisänen, S, Chen, X, Martins, CMMR, Young, M, Ott,TL, Kniffen, DM, Fabin, R, Hristov, AN. 2018. Production effects of extruded soybean meal in early lactation cow diets. Journal of Dairy Science, 102 (Suppl 2) Abst: 510.

 

Hester JM and Diaz FJ. 2018. Growing Oocytes Need Zinc: Zinc Deficiency in the Preantral Ovarian Follicle.  Experimental Biology Meeting, San Diego CA.  *Endocrinology and metabolism section research recognition award.

 

Hughes CK, Maalouf SW Liu W-S, Pate JL. 2019. Molecular profiling demonstrates modulation of immune cell function and matrix remodeling during luteal rescue. Biology of Reproduction, 2019, 0(0), 1–16 doi:10.1093/biolre/ioz037 Research Article Advance Access Publication Date: 27 March 2019

 

Hughes CK, Rogus A, Inskeep EK and Pate. 2018. Functional transitions in the corpus luteum are associated with changes in NR5A2 abundance, which regulates luteal progesterone production. Proc. 10th Int Ruminant Reprod Symp, Foz do Iguacu, Brazil

 

Hughes CK, Wetzel LM, Bosviel R, Newman J and Pate JL. 2018. Luteal metabolomics suggests a role for lipid mediators as regulators of cell death, cell migration, and immune function. Society for the Study of Reproduction, New Orleans, LA

 

Lupicka M and Pate JL. 2018. Luteal Extracellular Vesicles Carry MicroRNA and Modulate Cytokine Secretion from Immune Cells. Society for the Study of Reproduction, New Orleans, LA

 

Melgar, A, Harper, MT, Oh, J, Giallongo, F, Fetter, ME, Ott, TL, Duval, S, Hristov, AN. 2018. Effects of 3-nitrooxypropanol on rumen fermentation, lactational performance, and onset of ovarian activity in dairy cows. Journal of Dairy Science, 102 (Suppl 2) Abst: 209.

 

Ott, TL, Pate, JL. 2018. Effects of polymorphisms in GHR, IGFI and TNFA genes on fertility in lactating dairy cows. Journal of Dairy Science, 102 (Suppl 2) Abst. T207

 

Ott, TL., 2018. Immune recognition of the periattachment conceptus. Journal of Dairy Science, 102 (Suppl 2) Abst; 102.

 

Pate JL and Hughes CK. 2018. Applications of large-scale molecular profiling techniques to the study of the corpus luteum. Proc 10th Intl Ruminant Reproduction Symposium, Foz do Iguacu, Brazil

Ealy AD. 2019. Early Diagnosis of Pregnancy Loss. American Dairy Science Association Annual Meeting, Cincinnati OH.

 

Wooldridge LK, Johnson SE and Ealy AD. 2019. Interleukin-6 increases inner cell mass and hypoblast cell numbers in bovine blastocysts. Society for the Study of Reproduction 52nd Annual Meeting, San Jose CA.

 

Wooldridge LK and Ealy AD. 2019. STAT3 is required for hypoblast lineage development in bovine blastocysts. 2019. Society for Developmental Biology 78th Annual Meeting, Boston MA.

 

Cushman RA, Tenley SC, Spuri-Gomes R, Rosasco SL, Northrop EJ, Rich JRR, McNeel AK, Summers AF, Miles JR, Chase C, Lents CA, Perry GA, Wood JR, and Cupp AS. 2018. Influence of Maternal Age on Daughter Ovarian Reserve and Reproductive Longevity in Beef Cows. 51st Annual Meeting of the Society for the Study of Reproduction, New Orleans, LA

 

Neilson MA, Spuri-Gomes R, Romereim SM, Summers AF, Abedal-Majed MA, Tenley SC, Kurz SG, Bergman J, Davis JS, Wood JR, and Cupp AS. 2018. Altered Blood Plasma and Follicular Fluid Lipid Profiles Suggest Possible Discrepancies in Cell Signaling and Metabolism in Cows with Androgen Excess. 51st Annual Meeting of the Society for the Study of Reproduction, New Orleans, LA

 

Snider AP, Romereim SM, Summers AF, Pohlmeier WE, McFee RM, Spuri-Gomes R, Kurz SG, Davis JS, Wood JR, and Cupp AS. 2018. Exposure to Excess Androgen in the Ovarian Microenvironment of High A4 Cows Results in Altered Function of Granulosa Cells which may Explain Changes in Cyclicity and Response to Male Exposure. 51st Annual Meeting of the Society for the Study of Reproduction, New Orleans, LA

 

Hart ML, Abedal-Majed MA, Spuri-Gomes R, Snider AP, Kurz SG, Bergman JW, McFee RM, Casey CA, Davis JS, Cushman RA, Wood JR, and Cupp AS. 2018. Cyclicity Phenotype and Ovarian Cortex Androgen Secretion in Androgen Excess Cows are Predictive of Plasma Steroid and Lipids, Liver Enzymes, and Follicular Fluid Cytokines. 51st Annual Meeting of the Society for the Study of Reproduction, New Orleans, LA

 

Bochantin KA, Summers AF, Pohlmeier WE, Sargent KM, Kurz SG, Romereim SM, Daudu O, McFee RM, Cushman RA, Davis JS, Cupp AS, Wood JR. 2018.  Microarray Analysis Predicts that Differentially Expressed Genes in Theca Cells from Cows with High Intrafollicular Androstenedione are Regulated by ESR1 and VEGFA Signaling and Increased mRNA Stability. 51st Annual Meeting of the Society for the Study of Reproduction, New Orleans, LA

 

Timme KR, Miller HB, and Wood JR. Signaling of Pro-Inflammatory Cytokine TNFa through NFkB-p65 Increases Gdf9 and Decreases Figla mRNAs in Oocytes of Primary Follicles. 2018. 51st Annual Meeting of the Society for the Study of Reproduction, New Orleans, LA

 

McCain AR, Rister AL, Wordekemper M, Dodds ED, and Wood JR. 2018. Maternal obesity due to diet or loss of satiety differentially impacts fetal growth and placental efficiency which may be due to differences in excess circulating lipids. 51st Annual Meeting of the Society for the Study of Reproduction, New Orleans, LA

 

Theses/Dissertations

 

Hester, JM. The impact of zinc deficiency during oogenesis, follicle assembly, and growth. PhD Thesis in Physiology, Pennsylvania State University. Dec 2018.

 

Audra Harl. 2018. Factors affecting the quality and function of the bovine periovulatory follicle. (PhD Dissertation).

 

Sarah McCoski. 2018. Manipulating embryonic development and endometrial function in ruminants. (PhD Dissertation).

 

Lundberg, Townson DH. 2019 Investigation of Transforming Growth Factor-α and its potential role in promoting ovarian follicular dominance. UVM MS Thesis

 

Active collaboration within the group

 

NY, PA, NH, VT and WV:  Samples collected to investigate associations between fertility outcomes and SNP in candidate genes from dairy cows.

 

IA and UK: Samples shared to determine the effect of LPS treatment on ovarian inflammation.

 

PA and WV: Samples shared for analysis of molecular regulators of luteal function.

 

VT and NY: Samples assayed (NY) for analysis of progesterone concentrations.

 

 

In addition to Hatch Multistate Funds, these studies were supported by:

 

Iowa Pork Producers Association                                                                                               

 

National Pork Board

 

ISU Nutritional Sciences Council Martin Fund    

 

National Institute of Environmental Health Science - Agriculture and Food Research Initiative

 

National Institutes of Health

 

C. Lee Rumberger and Family Endowment

 

John L. Pratt Animal Nutrition Program

 

Virginia Agricultural Council Research Funding

 

University of Nebraska Foundation Funds

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